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Pharmacogenetics & MDMA It has been demonstrated that CYP2D6 poor metabolizers carrying only *3, *4, or *5 alleles administered MDMA reached an average maximum concentration (C max ) that is 19% higher and an initial drug exposure (AUC 0–6 h ) that is 25% higher than extensive metabolizers carrying only *1 and *2 alleles, which corresponded to a more rapid onset of subjective effects and elevated blood pressure (Schmid et al

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